Jameson Irish whiskey is created in a unique way compared to American and Scottish whisky. Jameson distil their whisky not once, like the American’s, not twice, which is the Scottish way but three times giving it the smoothest texture out of them all.

The John Jameson and Son Irish Whiskey company was formally established in 1810 when John Jameson and his son (also John Jameson) took ownership of the Bow Street Distillery in Dublin which had originally been built by his wife's cousins the Steins in 1780.

Jameson was a Scottish lawyer from Alloa in Clackmannanshire who had married Margaret Haig, a sister of the Haig brothers who owned the Haig distilleries. Margaret Haig was a first cousin of the Steins, a Scottish distilling family, also from Clackmannanshire, with significant distilling interests in Scotland and Dublin. On his marriage to Margaret Haig in 1786, John Jameson moved with his new wife to Dublin to manage the Stein's Bow Street Distillery (which had been established in 1780) for Margaret's Stein uncle. This explains the use of the year 1780 in Jameson marketing as the Bow Street Distillery was where Jameson Irish Whiskey was born. Portraits of John and Margaret Jameson by Sir Henry Raeburn are in the collection of the National Gallery of Ireland.

Originally one of the six main Dublin Whiskeys, Jameson is now distilled in Cork. In 2013, annual sales topped 4.7 million cases (56.4 million bottles). Jameson is by far the best selling Irish whiskey in the world, as it has been sold internationally since the early 19th century. The United States is the largest market for Jameson Whiskey, with consumption during 2013 up by 12%.